2025
Wang et al., 2025. Apo10 and TKTL1 in blood macrophages as non-invasive biomarkers for early detection of cervical cancer
2024
Xie et al., 2024. Apo10 and TKTL1 in blood macrophages as potential biomarkers for early diagnosis of operable breast cancer.
Zeberg, H.; Jakobsson, M.; & Pääbo, S. The genetic changes that shaped Neandertals, Denisovans, and modern humans. Cell, S0092-8674(23)01403-4. Advance online publication. 2024
2023
Brito-Rocha T., H.; Constâncio V..; Henrique R.; Jerónimo C. Shifting the Cancer Screening Paradigm: The Rising Potential of Blood-Based Multi-Cancer Early Detection Tests | Cells 2023
Shiming, H.; Qingfei M.; Huihui S.; et al. Human papillomavirus type 16 E6 promotes cervical cancer proliferation by upregulating transketolase enzymatic activity through the activation of protein kinase B. | Wiley Online Libaray 2023
Xie, C.; Wang, S.; Guo, C. et al. Apo10 and TKTL1 in blood macrophages as biomarkers for differentiating lung cancer from benign lung lesions: a comparative study with conventional biomarkers. | Cellular Oncology 2023
Burg, S.; Smeets, R.; Gosau, M.; Failing, K.; Grust, A. Case Report: Early detection of lung carcinoid in an asymptomatic individual by blood-test initiated PET-CT imaging. | Frontiers in Oncology 2023
Brito-Rocha, T.; Constâncio, V.; Henrique, R.; & Jerónimo, C. Shifting the Cancer Screening Paradigm: The Rising Potential of Blood-Based Multi-Cancer Early Detection Tests. Cells, 12(6), 935. 2023
2022
Li, Y.; Xu, C.; Wang, B.; Xu, F.; Ma, F. et al.: Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals new therapeutic strategies. | nature communications 2022
Pinson, A.; Xing, L.; Xinnan, L.; Namba, T.; Kalebic, N; Peters, J. et al. Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals. | Science 2022
Liu, Q.; Fangming, Z.; Xinnan, L.; Ying, L.; Ke, Y.; Na, T.; et al. Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics. | nature metabolism 2022
Hao, S.; Qingfei, M.; Huihui, S.; Yunkuo, L.; Yao, L.; et al. The role of transketolase in human cancer progression and therapy. | Elsevier 2022
Urla, C.; Stagno, M.J.; Schmidt, A.; Handgretinger, R.; Fuchs, J.; Warmann, S.W.; Schmid, E. Epitope Detection in Monocytes (EDIM) As a New Method of Liquid Biopsy in Pediatric Rhabdomyosarcoma. | Biomedicines 2022
Burg, S.; Grust, ALC.; Feyen, O.; Failing, K.; Banat, G-A.; Coy, JF. et al. Blood-Test Based Targeted Visualization Enables Early Detection of Premalignant and Malignant Tumors in Asymptomatic Individuals. | Journal of Clinical and Medical Images 2022;6.
Stagno, M.; Schmidt, A.; Bochem, J. et al. Epitope detection in monocytes (EDIM) for liquid biopsy including identification of GD2 in childhood neuroblastoma—a pilot study. | British Journal of Cancer 2022;7.
Baptista, I.; Karakitsou, E.; Cazier, J-B.; Günther, UL.; Marin, S.; Cascante, M. TKTL1 Knockdown Impairs Hypoxia-Induced Glucose-6-phosphate Dehydrogenase and Glyceraldehyde-3-phosphate Dehydrogenase Overexpression. | International Journal of Molecular Sciences 2022;23:3574.
Li, M.; Zhao, X.; Yong, H.; Xu, J.; Qu, P.; Qiao, S. et al. Transketolase promotes colorectal cancer metastasis through regulating AKT phosphorylation. | Cell Death & Disease 2022;13:99.
Niu, C.; Qiu, W.; Li, X.; Li, H.; Zhou, J.; Zhu, H. Transketolase Serves as a Biomarker for Poor Prognosis in Human Lung Adenocarcinoma. | Journal of Cancer 2022;13:2584–93.
Zhang, L.; Huang, Z.; Cai, Q.; Zhao, C.; Xiao, Y.; Quan, X. et al. Inhibition of Transketolase Improves the Prognosis of Colorectal Cancer. | Frontiers in Medicine 2022;9:837143.
2021
He, X.; Ding, J.; Cheng, X.; Xiong, M. Hypoxia-Related Gene-Based Signature Can Evaluate the Tumor Immune Microenvironment and Predict the Prognosis of Colon Adenocarcinoma Patients. International Journal of General Medicine 2021;14:9853–62.
Wang, J.; Li, Y.; Zhang, C.; Chen, X.; Zhu, L.; Luo, T. A hypoxia-linked gene signature for prognosis prediction and evaluating the immune microenvironment in patients with hepatocellular carcinoma. Translational Cancer Research 2021;10:3979–92.
Zhu, Y.; Qiu, Y.; Zhang, X. TKTL1 participated in malignant progression of cervical cancer cells via regulating AKT signal mediated PFKFB3 and thus regulating glycolysis. Cancer Cell International 2021;21:678.
Ahopelto, K.; Saukkonen, K.; Hagström, J.; Kauhanen, S.; Seppänen, H.; Böckelman, C. et al. TKTL1 as a Prognostic Marker in Pancreatic Ductal Adenocarcinoma and Its Correlation with FDG-PET-CT. Oncology 2021;99:177–85.
Cymbaluk-Płoska, A.; Chudecka, K.; Chudecka-Głaz, A.; Piotrowska, K.; Kwiatkowski, S.; Tarnowski, M. Importance of Potential New Biomarkers in Patient with Serouse Ovarian Cancer. Diagnostics (Basel). 2021;11:1026.
2020
Saman, S.; Stagno, MJ.; Warmann, SW.; Malek, NP.; Plentz, RR.; Schmid, E. Biomarkers Apo10 and TKTL1: Epitope-detection in monocytes (EDIM) as a new diagnostic approach for cholangiocellular, pancreatic and colorectal carcinoma. Cancer Biomark 2020;27:129–37.
Peltonen, R.; Ahopelto, K.; Hagström, J.; Böckelman, C.; Haglund, C.; Isoniemi, H. High TKTL1 expression as a sign of poor prognosis in colorectal cancer with synchronous rather than metachronous liver metastases. Cancer Biology & Therapy 2020;21:826–31.
Sequeda-JuÁrez, A.; JimÉnez, A.; Espinosa-Montesinos, A.; Del Carmen Cardenas-Aguayo, M.; RamÓn-Gallegos, E. Use of AKR1C1 and TKTL1 in the Diagnosis of Low-grade Squamous Intraepithelial Lesions from Mexican Women. Anticancer Research 2020;40:6273–84.
Ahopelto, K.; Laitinen, A.; Hagström, J.; Böckelman, C.; Haglund, C. Transketolase-Like Protein 1 and Glucose Transporter 1 in Gastric Cancer. Oncology 2020;98:643–52.
Van Gool, S. W.; Makalowski, J.; Bonner, E. R.; Feyen, O.; Domogalla, M. P.; Prix, L.; Schirrmacher, V.; Nazarian, J.; & Stuecker, W. . Addition of Multimodal Immunotherapy to Combination Treatment Strategies for Children with DIPG: A Single Institution Experience. Medicines (Basel, Switzerland), 7(5), 29.
2019
Chiarini, A.; Liu, D.; Rassu, M.; Armato, U.; Eccher, C.; Dal, Prà.; I. Over Expressed TKTL1, CIP-2A, and B-MYB Proteins in Uterine Cervix Epithelium Scrapings as Potential Risk Predictive Biomarkers in HR-HPV-Infected LSIL/ASCUS Patients. Frontiers Oncology 2019;9.
Li, Y.; Yao, C-F.; Xu, F-J.; Qu, Y-Y.; Li, J-T.; Lin, Y. et al. APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression. Nature Communications 2019;10:2502.
Liang, Y.; Song, J.; He, D.; Xia, Y.; Wu, Y.; Yin, X. et al. Systematic analysis of survival‐associated alternative splicing signatures uncovers prognostic predictors for head and neck cancer. Journal of Cellular Physiology 2019;234:15836–46.
2018
Zheng, X.; Li, H.: TKTL1 modulates the response of paclitaxel-resistant human ovarian cancer cells to paclitaxel. Biochemical and Biophysical Research Communications 2018
Heller, S.; Maurer, G.D.; Wanka, C.; Hofmann, U.; Luger, A.; Bruns, I. et al.: Gene Suppression of Transketolase-Like Protein 1 (TKTL1) Sensitizes Glioma Cells to Hypoxia and Ionizing Radiation. International Journal of Molecular Sciences 2018
2017
Todenhöfer, T.; Hennenlotter, J.; Keller, G.; Neumann, T.; Stenzl, A.; Bedke, J. Effect of radical prostatectomy on levels of cancer related epitopes in circulating macrophages of patients with clinically localized prostate cancer. Prostate 2017 Sep;77(12):1251-1258. doi: 10.1002/pros.23384. Epub 2017 Jul 20. PMID: 28726251.
Coy, JF. EDIM-TKTL1/Apo10 Blood Test: An Innate Immune System Based Liquid Biopsy for the Early Detection, Characterization and Targeted Treatment of Cancer. International Journal of Molecular Sciences 2017;18:878–95.
Burrai, GP.; Tanca, A.; Cubeddu, T.; Abbondio, M.; Polinas, M.; Addis, MF. et al. A first immunohistochemistry study of transketolase and transketolase-like 1 expression in canine hyperplastic and neoplastic mammary lesions. BMC Veterinary Research 2017;13:38.
2016
Grimm, M.; Hoefert, S.; Krimmel, M.; Biegner, T.; Feyen, O.; Teriete, P. et al. Monitoring carcinogenesis in a case of oral squamous cell carcinoma using a panel of new metabolic blood biomarkers as liquid biopsies. Journal of Oral and Maxillofacial Surgery 2016;20:295–302.
Diaz-Moralli, S.; Aguilar, E.; Marin, S.; Coy, JF.; Dewerchin, M.; Antoniewicz, MR. et al. A key role for transketolase-like 1 in tumor metabolic reprogramming. Oncotarget 2016;7:51875–97.
Grimm, M.; Feyen, O.; Coy, JF.; Hofmann, H.; Teriete, P.; Reinert, S. Analysis of circulating CD14+/CD16+ monocyte-derived macrophages (MDMs) in the peripheral blood of patients with oral squamous cell carcinoma. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology 2016;121:301–6.
Jayachandran, A.; Lo, P-H.; Chueh, AC.; Prithviraj, P.; Molania, R.; Davalos-Salas, M. et al. Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells. BMC Cancer 2016;16:134.
Xu, IM-J.; Lai, RK-H.; Lin, S-H.; Tse, AP-W.; Chiu, DK-C.; Koh, H-Y. et al. Transketolase counteracts oxidative stress to drive cancer development. Proceedings of the National Academy of Sciences of the United States of America 2016;113:E725.
Grimm, M.; Kraut, W.; Hoefert, S.; Krimmel, M.; Biegner, T.; Teriete, P. et al. Evaluation of a biomarker based blood test for monitoring surgical resection of oral squamous cell carcinomas. Clinical Oral Investigations 2016;20:329–38.
Ahopelto, K.; Böckelman, C.; Hagström, J.; Koskensalo, S.; Haglund, C. Transketolase-like protein 1 expression predicts poor prognosis in colorectal cancer. Cancer Biology & Therapy 2016;17:163–8.
Liberti, MV.; Locasale, JW. The Warburg Effect: How Does it Benefit Cancer Cells? Trends Biochem Sci. 2016;41:211–8.
Tsaur, I.; Thurn, K.; Juengel, E.; Oppermann, E.; Nelson, K.; Thomas, C. et al. Evaluation of TKTL1 as a biomarker in serum of prostate cancer patients. Central European Journal of Urology 2016;69:247–51.
2015
Song, Y.; Liu, D.; He, G. TKTL1 and p63 are biomarkers for the poor prognosis of gastric cancer patients. Cancer Biomark 2015;15:591–7.
Li, J.; Zhu, S-C.; Li, S-G.; Zhao, Y.; Xu, J-R.; Song, C-Y. TKTL1 promotes cell proliferation and metastasis in esophageal squamous cell carcinoma. Biomed Pharmacother 2015;74:71–6.
Ricciardelli, C.; Lokman, NA.; Cheruvu, S.; Tan, IA.; Ween, MP.; Pyragius, CE. et al. Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation. Clinical and Experimental Metastasis 2015;:1–15.
Shi, Z.; Tang, Y.; Li, K.; Fan, Q. TKTL1 expression and its downregulation is implicated in cell proliferation inhibition and cell cycle arrest in esophageal squamous cell carcinoma. Tumor Biology 2015;36:8519–29.
Benito, A.; Diaz-Moralli, S.; Coy, JF.; Centelles, JJ.; Cascante, M. Role of the Pentose Phosphate Pathway in Tumour Metabolism. In: Mazurek S, Shoshan M, editors. Tumor Cell Metabolism: Pathways, Regulation and Biology. Vienna: Springer 2015. p. 143–63.
Kämmerer, U.; Gires, O.; Pfetzer, N.; Wiegering, A.; Klement, RJ.; Otto, C. TKTL1 expression in human malign and benign cell lines. BMC Cancer 2015;15:2.
2014
Li, B.; Iglesias-Pedraz, JM.; Chen, L-Y.; Yin, F.; Cadenas, E.; Reddy, S, et al. Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells. Aging Cell 2014;13:367–78.
Grimm, M.; Cetindis, M.; Lehmann, M.; Biegner, T.; Munz, A.; Teriete, P. et al. Association of cancer metabolism-related proteins with oral carcinogenesis – indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma? Journal of Translational Medicine 2014;12:208.
Grimm, M.; Cetindis, M.; Lehmann, M.; Biegner, T.; Munz, A.; Teriete, P. et al. Apoptosis resistance-related ABCB5 and DNaseX (Apo10) expression in oral carcinogenesis. Acta Odontologica Scandinavica 2014;:1–7.
Grimm, M.; Munz, A.; Teriete, P.; Nadtotschi, T.; Reinert, S. GLUT-1+/TKTL1+ coexpression predicts poor outcome in oral squamous cell carcinoma. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 2014;117:743–53.
2013
Grimm, M.; Schmitt, S.; Teriete, P.; Biegner, T.; Stenzl, A.; Hennenlotter, J. et al. A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells. BMC Cancer 2013;13:569–86.
Grimm, M.; Hoefert, S.; Luz, O.; Reinert, S.; Polligkeit, J. Transketolase-like protein 1 expression in recurrent oral squamous cell carcinoma after curative resection: a case report. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology 2013;116:e173-178.
Jansen, N.; Coy, JF. Diagnostic use of epitope detection in monocytes blood test for early detection of colon cancer metastasis. Future Oncology. 2013;9:605–9.
Bentz, S.; Cee, A.; Endlicher, E.; Wojtal, KA.; Naami, A.; Pesch, T. et al. Hypoxia induces the expression of transketolase-like 1 in human colorectal cancer. Digestion. 2013;88:182–92.
Rotmann, A. The use of new diagnostic tests for the monitoring of new and existing therapies for breast cancer patients. JCO 2013;31 15_suppl:e22006–e22006.
2012
Feyen, O.; Coy, JF.; Prasad, V.; Schierl, R.; Saenger, J.; Baum, RP. EDIM-TKTL1 blood test: a noninvasive method to detect upregulated glucose metabolism in patients with malignancies. Future Oncology 2012;8:1349–59.
Lange, CA.; Tisch-Rottensteiner, J.; Böhringer, D.; Martin, G.; Schwartzkopff, J.; Auw-Haedrich, C. Enhanced TKTL1 expression in malignant tumors of the ocular adnexa predicts clinical outcome. Ophthalmol 2012;119:1924–9.
Wanka, C.; Steinbach, JP.; Rieger, J. Tp53-induced Glycolysis and Apoptosis Regulator (TIGAR) Protects Glioma Cells from Starvation-induced Cell Death by Up-regulating Respiration and Improving Cellular Redox Homeostasis. Journal of Biological Chemistry 2012;287:33436–46.
Wani, K.; Armstrong, T.; Vera-Bolanos, E.; Raghunathan, A.; Ellison, D.; Gilbertson, R. et al. A prognostic gene expression signature in infratentorial ependymoma. Acta Neuropathol 2012;123:727–38.
Rotmann, AR.; Coy, J. Apo10 – a new biomarker for early detection of disorders of cell proliferation and solid tumours. ABSTRACT FIGO 2012.
2011
Kayser, G.; Sienel, W.; Kubitz, B.; Mattern, D.; Stickeler, E.; Passlick, B. et al. Poor outcome in primary non-small cell lung cancers is predicted by transketolase TKTL1 expression. Pathology 2011;43:719–24.
Schwaab, J.; Horisberger, K.; Ströbel, P.; Bohn, B.; Gencer, D.; Kähler, G. et al. Expression of Transketolase like gene 1 (TKTL1) predicts disease-free survival in patients with locally advanced rectal cancer receiving neoadjuvant chemoradiotherapy. BMC Cancer. 2011;11:363.
Diaz-Moralli, S.; Tarrado-Castellarnau, M.; Alenda, C.; Castells, A.; Cascante, M. Transketolase-Like 1 Expression Is Modulated during Colorectal Cancer Progression and Metastasis Formation. PLoS One 2011;6.
Hartmannsberger, D.; Mack, B.; Eggert, C.; Denzel, S.; Steph, H.; Betz, CS. et al. Transketolase-like protein 1 confers resistance to serum withdrawal in vitro. Cancer Lett 2011;300:20–9.
Arnhold, J. Therapy monitoring and early detection of metastasis using tumor protein detection in macrophages. Anticancer Research 2011;31:2012.
Bentz, S.; Pesch, T.; Wolfram, L.; Vallière, C de.; Leucht, K.; Fried, M. et al. Lack of transketolase-like (TKTL) 1 aggravates murine experimental colitis. American Journal of Physiology – Gastrointestinal and Liver Physiology 2011;300:G598–607.