EDIM®, PanTum Detect®, TKTL1, DNaseX (Apo10)


Zeberg, H.; Jakobsson, M.; & Pääbo, S. The genetic changes that shaped Neandertals, Denisovans, and modern humans. Cell, S0092-8674(23)01403-4. Advance online publication. 2024


Brito-Rocha T., H.; Constâncio V..; Henrique R.; Jerónimo C. Shifting the Cancer Screening Paradigm: The Rising Potential of Blood-Based Multi-Cancer Early Detection Tests | Cells 2023

Shiming, H.; Qingfei M.; Huihui S.; et al. Human papillomavirus type 16 E6 promotes cervical cancer proliferation by upregulating transketolase enzymatic activity through the activation of protein kinase B. | Wiley Online Libaray 2023

Xie, C., Wang, S., Guo, C. et al. Apo10 and TKTL1 in blood macrophages as biomarkers for differentiating lung cancer from benign lung lesions: a comparative study with conventional biomarkers. | Cellular Oncology 2023

Burg S.; Smeets R.; Gosau M.; Failing K.; Grust A.: Case Report: Early detection of lung carcinoid in an asymptomatic individual by blood-test initiated PET-CT imaging. | Frontiers in Oncology 2023

Brito-Rocha, T.; Constâncio, V.; Henrique, R.; & Jerónimo, C. Shifting the Cancer Screening Paradigm: The Rising Potential of Blood-Based Multi-Cancer Early Detection Tests. Cells, 12(6), 935. 2024


Li Y.; Xu C.; Wang B.; Xu F.; Ma F. et al.: Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals new therapeutic strategies. | nature communications 2022

Pinson A.; Xing L.; Xinnan L.; Namba T.; Kalebic N; Peters J. et al.: Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals. | Science 2022

Liu Q.; Fangming Z.; Xinnan L.; Ying L.; Ke Y.; Na T.; et al.: Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics. | nature metabolism 2022

Hao S.; Qingfei, M.; Huihui S.; Yunkuo L.; Yao L.; et al.: The role of transketolase in human cancer progression and therapy. | Elsevier 2022

Urla, C.; Stagno, M.J.; Schmidt, A.; Handgretinger, R.; Fuchs, J.; Warmann, S.W.; Schmid, E. Epitope Detection in Monocytes (EDIM) As a New Method of Liquid Biopsy in Pediatric Rhabdomyosarcoma. | Biomedicines 2022

Burg S, Grust ALC, Feyen O, Failing K, Banat G-A, Coy JF, et al. Blood-Test Based Targeted Visualization Enables Early Detection of Premalignant and Malignant Tumors in Asymptomatic Individuals. | Journal of Clinical and Medical Images. 2022;6.

Stagno M, Schmidt A, Bochem J, et al. Epitope detection in monocytes (EDIM) for liquid biopsy including identification of GD2 in childhood neuroblastoma—a pilot study. | British Journal of Cancer. 2022;7.

Baptista I, Karakitsou E, Cazier J-B, Günther UL, Marin S, Cascante M. TKTL1 Knockdown Impairs Hypoxia-Induced Glucose-6-phosphate Dehydrogenase and Glyceraldehyde-3-phosphate Dehydrogenase Overexpression. | Int J Mol Sci. 2022;23:3574.

Li M, Zhao X, Yong H, Xu J, Qu P, Qiao S, et al. Transketolase promotes colorectal cancer metastasis through regulating AKT phosphorylation. | Cell Death Dis. 2022;13:99.

Niu C, Qiu W, Li X, Li H, Zhou J, Zhu H. Transketolase Serves as a Biomarker for Poor Prognosis in Human Lung Adenocarcinoma. | J Cancer. 2022;13:2584–93.

Zhang L, Huang Z, Cai Q, Zhao C, Xiao Y, Quan X, et al. Inhibition of Transketolase Improves the Prognosis of Colorectal Cancer. | Front Med. 2022;9:837143.


He X, Ding J, Cheng X, Xiong M. Hypoxia-Related Gene-Based Signature Can Evaluate the Tumor Immune Microenvironment and Predict the Prognosis of Colon Adenocarcinoma Patients. Int J Gen Med. 2021;14:9853–62.

Wang J, Li Y, Zhang C, Chen X, Zhu L, Luo T. A hypoxia-linked gene signature for prognosis prediction and evaluating the immune microenvironment in patients with hepatocellular carcinoma. Trans Cancer Res. 2021;10:3979–92.

Zhu Y, Qiu Y, Zhang X. TKTL1 participated in malignant progression of cervical cancer cells via regulating AKT signal mediated PFKFB3 and thus regulating glycolysis. Cancer Cell International. 2021;21:678.

Ahopelto K, Saukkonen K, Hagström J, Kauhanen S, Seppänen H, Böckelman C, et al. TKTL1 as a Prognostic Marker in Pancreatic Ductal Adenocarcinoma and Its Correlation with FDG-PET-CT. Oncology. 2021;99:177–85.

Cymbaluk-Płoska A, Chudecka K, Chudecka-Głaz A, Piotrowska K, Kwiatkowski S, Tarnowski M. Importance of Potential New Biomarkers in Patient with Serouse Ovarian Cancer. Diagnostics (Basel). 2021;11:1026.


Saman S, Stagno MJ, Warmann SW, Malek NP, Plentz RR, Schmid E. Biomarkers Apo10 and TKTL1: Epitope-detection in monocytes (EDIM) as a new diagnostic approach for cholangiocellular, pancreatic and colorectal carcinoma. Cancer Biomark. 2020;27:129–37.

Peltonen R, Ahopelto K, Hagström J, Böckelman C, Haglund C, Isoniemi H. High TKTL1 expression as a sign of poor prognosis in colorectal cancer with synchronous rather than metachronous liver metastases. Cancer Biol Ther. 2020;21:826–31.

Sequeda-JuÁrez A, JimÉnez A, Espinosa-Montesinos A, Del Carmen Cardenas-Aguayo M, RamÓn-Gallegos E. Use of AKR1C1 and TKTL1 in the Diagnosis of Low-grade Squamous Intraepithelial Lesions from Mexican Women. Anticancer Res. 2020;40:6273–84.

Ahopelto K, Laitinen A, Hagström J, Böckelman C, Haglund C. Transketolase-Like Protein 1 and Glucose Transporter 1 in Gastric Cancer. Oncology. 2020;98:643–52.

Van Gool, S. W.; Makalowski, J.; Bonner, E. R.; Feyen, O.; Domogalla, M. P.; Prix, L.; Schirrmacher, V.; Nazarian, J.; & Stuecker, W. . Addition of Multimodal Immunotherapy to Combination Treatment Strategies for Children with DIPG: A Single Institution Experience. Medicines (Basel, Switzerland)7(5), 29.


Chiarini A, Liu D, Rassu M, Armato U, Eccher C, Dal Prà I. Over Expressed TKTL1, CIP-2A, and B-MYB Proteins in Uterine Cervix Epithelium Scrapings as Potential Risk Predictive Biomarkers in HR-HPV-Infected LSIL/ASCUS Patients. Front Oncol. 2019;9.

Li Y, Yao C-F, Xu F-J, Qu Y-Y, Li J-T, Lin Y, et al. APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression. Nat Commun. 2019;10:2502.

Liang Y, Song J, He D, Xia Y, Wu Y, Yin X, et al. Systematic analysis of survival‐associated alternative splicing signatures uncovers prognostic predictors for head and neck cancer. J Cell Physiol. 2019;234:15836–46.

Zhao M, Ye M, Zhou J, Zhu X. Prognostic values of transketolase family genes in ovarian cancer. Oncol Lett. 2019;18:4845–57.


Zheng, X.; Li, H.: TKTL1 modulates the response of paclitaxel-resistant human ovarian cancer cells to paclitaxel. Biochemical and Biophysical Research Communications 2018

Heller, S.; Maurer, G.D.; Wanka, C.; Hofmann, U.; Luger, A.; Bruns, I. et al.: Gene Suppression of Transketolase-Like Protein 1 (TKTL1) Sensitizes Glioma Cells to Hypoxia and Ionizing Radiation. International Journal of Molecular Sciences 2018


Coy JF. EDIM-TKTL1/Apo10 Blood Test: An Innate Immune System Based Liquid Biopsy for the Early Detection, Characterization and Targeted Treatment of Cancer. Int J Mol Sci. 2017;18:878–95.

Burrai GP, Tanca A, Cubeddu T, Abbondio M, Polinas M, Addis MF, et al. A first immunohistochemistry study of transketolase and transketolase-like 1 expression in canine hyperplastic and neoplastic mammary lesions. BMC Veterinary Research. 2017;13:38.

Dong, Y.; Wang, M.: Knockdown of TKTL1 additively complements cisplatin-induced cytotoxicity in nasopharyngeal carcinoma cells by regulating the levels of NADPH and ribose-5-phosphate. Biomedicine & Pharmacotherapy 2017;85


Grimm M, Hoefert S, Krimmel M, Biegner T, Feyen O, Teriete P, et al. Monitoring carcinogenesis in a case of oral squamous cell carcinoma using a panel of new metabolic blood biomarkers as liquid biopsies. Oral Maxillofac Surg. 2016;20:295–302.

Diaz-Moralli S, Aguilar E, Marin S, Coy JF, Dewerchin M, Antoniewicz MR, et al. A key role for transketolase-like 1 in tumor metabolic reprogramming. Oncotarget. 2016;7:51875–97.

Grimm M, Feyen O, Coy JF, Hofmann H, Teriete P, Reinert S. Analysis of circulating CD14+/CD16+ monocyte-derived macrophages (MDMs) in the peripheral blood of patients with oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;121:301–6.

Jayachandran A, Lo P-H, Chueh AC, Prithviraj P, Molania R, Davalos-Salas M, et al. Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells. BMC Cancer. 2016;16:134.

Xu IM-J, Lai RK-H, Lin S-H, Tse AP-W, Chiu DK-C, Koh H-Y, et al. Transketolase counteracts oxidative stress to drive cancer development. Proc Natl Acad Sci USA. 2016;113:E725.

Grimm M, Kraut W, Hoefert S, Krimmel M, Biegner T, Teriete P, et al. Evaluation of a biomarker based blood test for monitoring surgical resection of oral squamous cell carcinomas. Clinical Oral Investigations. 2016;20:329–38.

Ahopelto K, Böckelman C, Hagström J, Koskensalo S, Haglund C. Transketolase-like protein 1 expression predicts poor prognosis in colorectal cancer. Cancer Biol Ther. 2016;17:163–8.

Liberti MV, Locasale JW. The Warburg Effect: How Does it Benefit Cancer Cells? Trends Biochem Sci. 2016;41:211–8.

Tsaur I, Thurn K, Juengel E, Oppermann E, Nelson K, Thomas C, et al. Evaluation of TKTL1 as a biomarker in serum of prostate cancer patients. Cent European J Urol. 2016;69:247–51.


Song Y, Liu D, He G. TKTL1 and p63 are biomarkers for the poor prognosis of gastric cancer patients. Cancer Biomark. 2015;15:591–7.

Li J, Zhu S-C, Li S-G, Zhao Y, Xu J-R, Song C-Y. TKTL1 promotes cell proliferation and metastasis in esophageal squamous cell carcinoma. Biomed Pharmacother. 2015;74:71–6.

Ricciardelli C, Lokman NA, Cheruvu S, Tan IA, Ween MP, Pyragius CE, et al. Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation. Clin Exp Metastasis. 2015;:1–15.

Shi Z, Tang Y, Li K, Fan Q. TKTL1 expression and its downregulation is implicated in cell proliferation inhibition and cell cycle arrest in esophageal squamous cell carcinoma. Tumour Biol. 2015;36:8519–29.

Benito A, Diaz-Moralli S, Coy JF, Centelles JJ, Cascante M. Role of the Pentose Phosphate Pathway in Tumour Metabolism. In: Mazurek S, Shoshan M, editors. Tumor Cell Metabolism: Pathways, Regulation and Biology. Vienna: Springer; 2015. p. 143–63.

Kämmerer U, Gires O, Pfetzer N, Wiegering A, Klement RJ, Otto C. TKTL1 expression in human malign and benign cell lines. BMC Cancer. 2015;15:2.


Li B, Iglesias-Pedraz JM, Chen L-Y, Yin F, Cadenas E, Reddy S, et al. Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells. Aging Cell. 2014;13:367–78.

Grimm M, Cetindis M, Lehmann M, Biegner T, Munz A, Teriete P, et al. Association of cancer metabolism-related proteins with oral carcinogenesis – indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma? J Transl Med. 2014;12:208.

Grimm M, Cetindis M, Lehmann M, Biegner T, Munz A, Teriete P, et al. Apoptosis resistance-related ABCB5 and DNaseX (Apo10) expression in oral carcinogenesis. Acta Odontol Scand. 2014;:1–7.

Grimm M, Munz A, Teriete P, Nadtotschi T, Reinert S. GLUT-1+/TKTL1+ coexpression predicts poor outcome in oral squamous cell carcinoma. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2014;117:743–53.

Japink D, Nap M, Sosef MN, Nelemans PJ, Coy JF, Beets G, et al. Reproducibility studies for experimental epitope detection in macrophages (EDIM). J Immunol Methods. 2014;407:40–7.


Grimm M, Schmitt S, Teriete P, Biegner T, Stenzl A, Hennenlotter J, et al. A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells. BMC Cancer. 2013;13:569–86.

Grimm M, Hoefert S, Luz O, Reinert S, Polligkeit J. Transketolase-like protein 1 expression in recurrent oral squamous cell carcinoma after curative resection: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116:e173-178.

Jansen N, Coy JF. Diagnostic use of epitope detection in monocytes blood test for early detection of colon cancer metastasis. Future Oncology. 2013;9:605–9.

Bentz S, Cee A, Endlicher E, Wojtal KA, Naami A, Pesch T, et al. Hypoxia induces the expression of transketolase-like 1 in human colorectal cancer. Digestion. 2013;88:182–92.

Rotmann A. The use of new diagnostic tests for the monitoring of new and existing therapies for breast cancer patients. JCO. 2013;31 15_suppl:e22006–e22006.


Feyen O, Coy JF, Prasad V, Schierl R, Saenger J, Baum RP. EDIM-TKTL1 blood test: a noninvasive method to detect upregulated glucose metabolism in patients with malignancies. Future Oncol. 2012;8:1349–59.

Lange CA, Tisch-Rottensteiner J, Böhringer D, Martin G, Schwartzkopff J, Auw-Haedrich C. Enhanced TKTL1 expression in malignant tumors of the ocular adnexa predicts clinical outcome. Ophthalmol. 2012;119:1924–9.

Wanka C, Steinbach JP, Rieger J. Tp53-induced Glycolysis and Apoptosis Regulator (TIGAR) Protects Glioma Cells from Starvation-induced Cell Death by Up-regulating Respiration and Improving Cellular Redox Homeostasis. J Biol Chem. 2012;287:33436–46.

Wani K, Armstrong T, Vera-Bolanos E, Raghunathan A, Ellison D, Gilbertson R, et al. A prognostic gene expression signature in infratentorial ependymoma. Acta Neuropathol. 2012;123:727–38.

Rotmann AR, Coy J. Apo10 – a new biomarker for early detection of disorders of cell proliferation and solid tumours ABSTRACT FIGO 2012. 2012.


Kayser G, Sienel W, Kubitz B, Mattern D, Stickeler E, Passlick B, et al. Poor outcome in primary non-small cell lung cancers is predicted by transketolase TKTL1 expression. Pathology. 2011;43:719–24.

Schwaab J, Horisberger K, Ströbel P, Bohn B, Gencer D, Kähler G, et al. Expression of Transketolase like gene 1 (TKTL1) predicts disease-free survival in patients with locally advanced rectal cancer receiving neoadjuvant chemoradiotherapy. BMC Cancer. 2011;11:363.

Diaz-Moralli S, Tarrado-Castellarnau M, Alenda C, Castells A, Cascante M. Transketolase-Like 1 Expression Is Modulated during Colorectal Cancer Progression and Metastasis Formation. PLoS One. 2011;6.

Hartmannsberger D, Mack B, Eggert C, Denzel S, Stepp H, Betz CS, et al. Transketolase-like protein 1 confers resistance to serum withdrawal in vitro. Cancer Lett. 2011;300:20–9.

Arnhold J. Therapy monitoring and early detection of metastasis using tumor protein detection in macrophages. Anticancer Res. 2011;31:2012.

Bentz S, Pesch T, Wolfram L, Vallière C de, Leucht K, Fried M, et al. Lack of transketolase-like (TKTL) 1 aggravates murine experimental colitis. American Journal of Physiology – Gastrointestinal and Liver Physiology. 2011;300:G598–607.