Company

Technology Excellence in Darmstadt

About us - Zyagnum AG

Zyagnum is a biotechnology company with the goal of making serious diseases visible and thus treatable at the earliest possible stage. We are convinced that many diseases can be treated and cured better the earlier they are detected. Therefore, we believe that the key to curing the major unsolved medical problems of our time lies in early detection diagnostics.

Since 2007, we have been working with our long-established core team and close partners to develop technologies that can detect these common diseases earlier. The result of this intensive development period is our proprietary EDIM® Technology.

With approx. 50 employees at the Darmstadt site as well as numerous close business partners in Germany and abroad, we are now working on the implementation of our ideas for diagnostics.

Technology Excellence
aus Darmstadt

Zyagnum AG

Zyagnum is a biotechnology company with the goal of making serious diseases visible and thus treatable at the earliest possible stage. We are convinced that many diseases can be treated and cured better the earlier they are detected. Therefore, we believe that the key to curing the major unsolved medical problems of our time lies in early detection diagnostics.

Since 2007, we have been working with our long-established core team and close partners to develop technologies that can detect these common diseases earlier. The result of this intensive development period is our proprietary EDIM® Technology.

With more than 30 employees at the Darmstadt site as well as numerous close business partners in Germany and abroad, we are now working on the implementation of our ideas for diagnostics.

A NEW CHAPTER IN DIAGNOSTICS

OUR MISSION

We are convinced that the earliest possible detection of diseases is the prerequisite for the best possible treatments and optimal chances of recovery.

That is why we are driven by the vision of making chronic health imbalances diagnosable even before the disease can manifest itself. This is the prerequisite for turning the early detection of life-changing diseases such as cancer, Alzheimer’s or diabetes into true prevention.

Our aim is to make our diagnostics as simple, cost-effective, and burden-free as possible so that as many people as possible can benefit from them.

A NEW CHAPTER IN DIAGNOSTICS

OUR MISSION

We are convinced that the earliest possible detection of diseases is the prerequisite for the best possible treatments and optimal chances of recovery.

That is why we are driven by the vision of making chronic health imbalances diagnosable even before the disease can manifest itself. This is the prerequisite for turning the early detection of life-changing diseases such as cancer, Alzheimer’s or diabetes into true prevention.

Our aim is to make our diagnostics as simple, cost-effective, and burden-free as possible so that as many people as possible can benefit from them.

Read more about the innovative EDIM-Technologie

Zyagnum AG

Company- History

Zyagnum AG

Company History

Based on a unique discovery, we aim to usher in a new era in the early detection of serious diseases.

1995

DISCOVERY TKTL1

At the German Cancer Research Institute (DKFZ), Dr. Johannes Coy discovers the gene and enzyme TKTL1. TKTL1 controls cell division and is the decisive factor in the formation of new cells.
2007

FOUNDATION OF ZYAGNUM AG

Zyagnum AG is founded with the vision to develop a technology platform for the early detection of serious diseases and to develop a screening test for cancer.
2010

FIRST IN-HOUSE TEST

First trial blood test for cancer based on the marker TKTL1 with encouraging results.

In the following years, Zyagnum added the additional parameter DNaseX (Apo10) to the test. This indicates that the programmed death of cancer cells (apoptosis) is disrupted.

2013

COMBINED SCORE OF DNASEX (APO10) AND TKTL1 PROVIDES BEST DISCRIMINATION

A performance study (BMC Cancer) using oral cavity carcinomas, breast cancer, and prostate cancer shows that the combination of DNaseX (Apo10) and TKTL1 leads to the best possible discrimination between cancer patients and healthy individuals. This lays the foundation for the PanTum Detect® test to be applied in the early detection of cancer.
2017

DEVELOPMENT COMPLETED

Completion of the development of the EDIM® technology (Epitope Detection in Monocytes).

PanTum Detect® is officially approved as a medical product in the EU.

2018 - 2020

PANTUM DETECT® INTERNATIONAL

Agreements of long-term international development and cooperation partnerships in China, India and Southeast Asia. The aim is to market the PanTum Detect® and other possible test methods widely in these regions.
2019

PIONEERING PUBLICATION

Publication in the high-ranking scientific journal “Nature Communications” journal confirms: TKTL1 controls cell cycleof cancer cells.
2022

SCREENING STUDY

Publication of interim results of a large screening study at the University Medical Center Hamburg-Eppendorf on the combination of PanTum Detect® and – in case of positive results – subsequent imaging diagnostics (PET/CT and MRI). More than 5,000 subjects without symptoms or cancer history take part in the study.
2023

SCREENING PANTUM DETECT® AS PART OF INSURANCE: KREBS-SCAN

Marketing launch of PanTum Detect® in Germany as “Krebs-Scan” insurance together with HanseMerkur insurance group.

Zyagnum Management

Ralf Schierl
Founder & CEO

Hendrik Krämer-Sohns
CFO / Head of Finance & Sales

Anette Ludwig
COO

Dr. Oliver Feyen
CSO (Chief Scientific Officer)